Test: Serum IgE Test - Cat dander

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Background/Purpose

Cat-allergic patients with IgE antibodies to Fel d 1 have been shown also to react to the corresponding protein of ocelot, puma, serval, siberian tiger, lion, jaguar, and snow leopard. A subgroup of cat-allergic patients also react to dogs and sometimes to other animals. Serum albumin is the main common component. Extensive cross-reactivity even occurs between albumins of distantly related species and subjects with IgE antibodies to cat albumin may also react to horse, cattle, pig, rodents, and fur animals like mink and fox. However, great variability exists between patients and selective sensitivity to limited numbers of species occurs, indicating shared and specific epitopes. Common and species-restricted epitopes have also been observed on the major cat and dog allergens Fel d 1 and Can f 1. Allergy to cat dander and pork meat, also referred to as the pork/cat syndrome, was shown to be mediated by IgE antibodies recognizing cat and pig serum albumin. In addition, other kinds of meat may be a risk for patients with this type of sensitivity, as indicated by a case with cat-specific IgE antibodies and exercise-induced anaphylaxis after eating pork or beef.

Procedure

A blood sample is obtained from the patient, typically from a venipuncture.
The sample is stored in a red cap vile.
Testing is performed in a lab using an ELISA analyzer or similar technology.
Performed: Bilaterally

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Serum specific IgE Test - Cat dander

Criteria

• Low reading on scale

Measurement

LOINC Code

6833-8

Scale/Grading

selection range; grade - LOINC ID
Option - Value option selection range; grade - LOINC IDNegative < 0.01 ; Pass - LA6111-4Equivocal-Low between 0.1-0.31 ; Fail - LA6112-2Low between 0.32-0.55 ; Fail - LA6113-0Moderate between 0.56-1.4 ; Fail - LA6114-8High between 1.4-3.9 ; Fail - LA6115-5Very High between 3.91-19 ; Fail - LA10137-0Extremely High > 19 ; Fail - LA10138-8